Aging is applied at character creation and every time a character ages 1 year (naturally or unnaturally).
Some important notes:
-1 and +1 should be applied). But if the character hits Mature during play, the +1 STR should be applied even though the character didn't lose the -1 during character creation. Put another way, there is no need to track being “in the hole” for aging, and there should be no occasion for a player to note on their character sheet that they “owe” a point of STR.